This is an ergot alkaloid now approved as an adjunctive therapy with carbidopa/levodopa for those patients who develop tolerance and end-of-dose failure to levodopa.10 After addition of bromocriptine, dose of levodopa should be reduced. Bromocriptine can be used as a single agent in the treatment of early or mild PD.

• History of mental illness
• Recent heart attack
• Peptic ulcer disease (bleeding from pergolide has been reported)
• History of peripheral vascular disease

• Hallucinations
• Confusion
• Nausea
• Postural hypotension
• Motor disturbances
• Mental changes